Thaum ntxov 2025, cov kws tshawb fawb los ntawm University of Washington thiab Brigham thiab Cov Tsev Kho Mob Poj Niam (lub tsev kho mob qhia ntawm Harvard Medical School) tau qhia txog txoj hauv kev uas tsis tau pom dua los kho Alzheimer's disease - nqus pa.xenonroj, uas tsis tsuas yog inhibits neuroinflamation thiab txo lub hlwb atrophy, tab sis kuj nce kev tiv thaiv neuronal xeev.

Xenonthiab Neuroprotection

Alzheimer's kab mob yog cov kab mob neurodegenerative tshaj plaws hauv tib neeg, thiab nws qhov laj thawj tau ntseeg tias muaj feem cuam tshuam nrog kev sib sau ntawm tau protein ntau thiab beta-amyloid protein nyob rau hauv lub hlwb. Txawm hais tias muaj cov tshuaj uas sim tshem tawm cov tshuaj lom cov proteins no, lawv tsis tau muaj txiaj ntsig hauv kev ua kom qeeb ntawm tus kab mob. Yog li ntawd, tsis yog lub hauv paus ua rau tus kab mob los yog kev kho mob yog to taub tag nrho.

Kev tshawb fawb tau pom tias nqus tauxenontuaj yeem hla cov hlab ntsha-hlwb thiab txhim kho cov xwm txheej ntawm cov nas nrog Alzheimer's kab mob qauv hauv kev kuaj mob.Qhov kev sim tau muab faib ua ob pawg, ib pab nas pom tau cov protein ntau thiab lwm pab pawg muaj beta-amyloid protein ntau. Cov txiaj ntsig kev sim tau pom tias xenon tsis tsuas yog ua rau cov nas muaj zog, tab sis kuj txhawb kev tiv thaiv cov lus teb ntawm microglia, uas yog qhov tseem ceeb rau kev tshem tawm tau thiab beta-amyloid proteins.

Qhov kev tshawb pom tshiab no yog qhov tshiab heev, qhia tias cov teebmeem neuroprotective tuaj yeem tsim tau yooj yim los ntawm kev nqus cov pa roj. Ib qho kev txwv loj hauv kev tshawb fawb thiab kev kho mob Alzheimer yog qhov nyuaj heev los tsim cov tshuaj uas tuaj yeem hla cov ntshav-hlwb teeb meem, thiabxenontuaj yeem ua qhov no.

Lwm daim ntawv thov kev kho mob ntawm xenon

1. Tshuaj loog thiab tshuaj loog: Raws li cov tshuaj loog zoo tagnrho,xenonyog dav siv vim nws ceev induction thiab rov qab, zoo plawv stability thiab tsis tshua muaj kev phiv;

2. Cov nyhuv neuroprotective: Ntxiv rau qhov muaj peev xwm kho tau ntawm Alzheimer's tus kab mob tau hais los saum no, xenon kuj tau kawm los txo cov hlwb puas tsuaj los ntawm neonatal hypoxic-ischemic encephalopathy (HIE);

3. Kev hloov cev thiab kev tiv thaiv:Xenontuaj yeem pab tiv thaiv tus neeg pub khoom nruab nrog cev los ntawm ischemia-reperfusion raug mob, uas yog ib qho tseem ceeb heev rau kev txhim kho qhov kev vam meej ntawm kev hloov pauv;

4. Radiotherapy rhiab heev: Qee qhov kev tshawb fawb ua ntej tau pom tias xenon tuaj yeem txhim kho qhov rhiab heev ntawm cov qog nqaij hlav rau kev siv hluav taws xob, uas muab lub tswv yim tshiab rau kev kho mob qog noj ntshav;